Is the evidence base of methylphenidate for children and adolescents with attention-deficit/hyperactivity disorder flawed?

Methylphenidate for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

CLINICAL QUESTION Is treatment with methylphenidate associated with benefits or harms for children and adolescents with attention-deficit/hyperactivity disorder (ADHD)? BOTTOM LINE Methylphenidate is associated with improvement in ADHD symptoms, general behavior, and quality of life; however, due to the very low quality of the evidence, the magnitude of the associated improvement is uncertain...

Effect of methylphenidate on sleep status of children with attention deficit hyperactivity disorder

Introduction: Sleep disorders are one of the most important problems in children with attention deficit hyperactivity disorder. Methylphenidate has different effects on the sleep parameters of affected children. The aim of this study was to evaluate the sleep status of children with attention deficit hyperactivity disorder (ADHD) before and after methylphenidate use. Materials and Methods: This...

Comparative efficacy of methylphenidate and atomoxetine in the treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review and meta-analysis

Background: The aim of this study was to directly compare efficacy of atomoxetine and methylphenidate in treatment of children and adolescents 6- 18 years.   Methods: All published, randomized, open label or double blind trials, comparing the efficacy of methylphenidate with atomoxetine in treatment of children diagnosed with ADHD, using DSM-IV criteria were included in this study; ADHD...

Review: short acting methylphenidate has short term efficacy in children and adolescents with attention deficit disorder.

The effect of methylphenidate on sustained attention among adolescents with attention-deficit hyperactivity disorder.

Twenty-seven adolescents diagnosed as having attention-deficit hyperactivity disorder (ADHD) were tested twice with a computerized MATH-CPT (mathematics continuous performance test). In one administration, the participants took medication (methylphenidate, MPH) 1.5 hr before being tested. In another administration, the MATH-CPT was administered without the medication. Treatment with MPH improve...